A single gene underlies the dynamic evolution of poplar sex determination.
Identifieur interne : 000589 ( Main/Exploration ); précédent : 000588; suivant : 000590A single gene underlies the dynamic evolution of poplar sex determination.
Auteurs : Niels A. Müller [Allemagne] ; Birgit Kersten [Allemagne] ; Ana P. Leite Montalvão [Allemagne] ; Niklas M Hler [Suède] ; Carolina Bernhardsson [Suède] ; Katharina Br Utigam [Canada] ; Zulema Carracedo Lorenzo [Suède] ; Hans Hoenicka [Allemagne] ; Vikash Kumar [Suède] ; Malte Mader [Allemagne] ; Birte Pakull [Allemagne] ; Kathryn M. Robinson [Suède] ; Maurizio Sabatti [Italie] ; Cristina Vettori [Italie] ; P R K. Ingvarsson [Suède] ; Quentin Cronk [Canada] ; Nathaniel R. Street [Suède] ; Matthias Fladung [Allemagne]Source :
- Nature plants [ 2055-0278 ] ; 2020.
Abstract
Although hundreds of plant lineages have independently evolved dioecy (that is, separation of the sexes), the underlying genetic basis remains largely elusive1. Here we show that diverse poplar species carry partial duplicates of the ARABIDOPSIS RESPONSE REGULATOR 17 (ARR17) orthologue in the male-specific region of the Y chromosome. These duplicates give rise to small RNAs apparently causing male-specific DNA methylation and silencing of the ARR17 gene. CRISPR-Cas9-induced mutations demonstrate that ARR17 functions as a sex switch, triggering female development when on and male development when off. Despite repeated turnover events, including a transition from the XY system to a ZW system, the sex-specific regulation of ARR17 is conserved across the poplar genus and probably beyond. Our data reveal how a single-gene-based mechanism of dioecy can enable highly dynamic sex-linked regions and contribute to maintaining recombination and integrity of sex chromosomes.
DOI: 10.1038/s41477-020-0672-9
PubMed: 32483326
Affiliations:
- Allemagne, Canada, Italie, Suède
- Colombie-Britannique
- Vancouver
- Université de la Colombie-Britannique
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Müller</name><affiliation wicri:level="1"><nlm:affiliation>Thünen Institute of Forest Genetics, Grosshansdorf, Germany. niels.mueller@thuenen.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Thünen Institute of Forest Genetics, Grosshansdorf</wicri:regionArea><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion></affiliation></author><author><name sortKey="Kersten, Birgit" sort="Kersten, Birgit" uniqKey="Kersten B" first="Birgit" last="Kersten">Birgit Kersten</name><affiliation wicri:level="1"><nlm:affiliation>Thünen Institute of Forest Genetics, Grosshansdorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Thünen Institute of Forest Genetics, Grosshansdorf</wicri:regionArea><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion></affiliation></author><author><name sortKey="Leite Montalvao, Ana P" sort="Leite Montalvao, Ana P" uniqKey="Leite Montalvao A" first="Ana P" last="Leite Montalvão">Ana P. Leite Montalvão</name><affiliation wicri:level="1"><nlm:affiliation>Thünen Institute of Forest Genetics, Grosshansdorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Thünen Institute of Forest Genetics, Grosshansdorf</wicri:regionArea><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion></affiliation></author><author><name sortKey="M Hler, Niklas" sort="M Hler, Niklas" uniqKey="M Hler N" first="Niklas" last="M Hler">Niklas M Hler</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Physiology, Umeå Plant Science Centre, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Plant Physiology, Umeå Plant Science Centre, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Bernhardsson, Carolina" sort="Bernhardsson, Carolina" uniqKey="Bernhardsson C" first="Carolina" last="Bernhardsson">Carolina Bernhardsson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Biology, Linnean Centre for Plant Biology, Swedish University of Agricultural Sciences, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Plant Biology, Linnean Centre for Plant Biology, Swedish University of Agricultural Sciences, Uppsala</wicri:regionArea><wicri:noRegion>Uppsala</wicri:noRegion></affiliation></author><author><name sortKey="Br Utigam, Katharina" sort="Br Utigam, Katharina" uniqKey="Br Utigam K" first="Katharina" last="Br Utigam">Katharina Br Utigam</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biology, University of Toronto Mississauga, Mississauga, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biology, University of Toronto Mississauga, Mississauga, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Carracedo Lorenzo, Zulema" sort="Carracedo Lorenzo, Zulema" uniqKey="Carracedo Lorenzo Z" first="Zulema" last="Carracedo Lorenzo">Zulema Carracedo Lorenzo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Physiology, Umeå Plant Science Centre, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Plant Physiology, Umeå Plant Science Centre, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Hoenicka, Hans" sort="Hoenicka, Hans" uniqKey="Hoenicka H" first="Hans" last="Hoenicka">Hans Hoenicka</name><affiliation wicri:level="1"><nlm:affiliation>Thünen Institute of Forest Genetics, Grosshansdorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Thünen Institute of Forest Genetics, Grosshansdorf</wicri:regionArea><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion></affiliation></author><author><name sortKey="Kumar, Vikash" sort="Kumar, Vikash" uniqKey="Kumar V" first="Vikash" last="Kumar">Vikash Kumar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Physiology, Umeå Plant Science Centre, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Plant Physiology, Umeå Plant Science Centre, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Mader, Malte" sort="Mader, Malte" uniqKey="Mader M" first="Malte" last="Mader">Malte Mader</name><affiliation wicri:level="1"><nlm:affiliation>Thünen Institute of Forest Genetics, Grosshansdorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Thünen Institute of Forest Genetics, Grosshansdorf</wicri:regionArea><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion></affiliation></author><author><name sortKey="Pakull, Birte" sort="Pakull, Birte" uniqKey="Pakull B" first="Birte" last="Pakull">Birte Pakull</name><affiliation wicri:level="1"><nlm:affiliation>Thünen Institute of Forest Genetics, Grosshansdorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Thünen Institute of Forest Genetics, Grosshansdorf</wicri:regionArea><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion></affiliation></author><author><name sortKey="Robinson, Kathryn M" sort="Robinson, Kathryn M" uniqKey="Robinson K" first="Kathryn M" last="Robinson">Kathryn M. Robinson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Physiology, Umeå Plant Science Centre, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Plant Physiology, Umeå Plant Science Centre, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Sabatti, Maurizio" sort="Sabatti, Maurizio" uniqKey="Sabatti M" first="Maurizio" last="Sabatti">Maurizio Sabatti</name><affiliation wicri:level="1"><nlm:affiliation>Department for Innovation in Biological, Agro-food and Forest Systems, University of Tuscia, Viterbo, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department for Innovation in Biological, Agro-food and Forest Systems, University of Tuscia, Viterbo</wicri:regionArea><wicri:noRegion>Viterbo</wicri:noRegion></affiliation></author><author><name sortKey="Vettori, Cristina" sort="Vettori, Cristina" uniqKey="Vettori C" first="Cristina" last="Vettori">Cristina Vettori</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biosciences and BioResources, Division of Florence, National Research Council, Sesto Fiorentino, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Biosciences and BioResources, Division of Florence, National Research Council, Sesto Fiorentino</wicri:regionArea><wicri:noRegion>Sesto Fiorentino</wicri:noRegion></affiliation></author><author><name sortKey="Ingvarsson, P R K" sort="Ingvarsson, P R K" uniqKey="Ingvarsson P" first="P R K" last="Ingvarsson">P R K. Ingvarsson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Biology, Linnean Centre for Plant Biology, Swedish University of Agricultural Sciences, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Plant Biology, Linnean Centre for Plant Biology, Swedish University of Agricultural Sciences, Uppsala</wicri:regionArea><wicri:noRegion>Uppsala</wicri:noRegion></affiliation></author><author><name sortKey="Cronk, Quentin" sort="Cronk, Quentin" uniqKey="Cronk Q" first="Quentin" last="Cronk">Quentin Cronk</name><affiliation wicri:level="4"><nlm:affiliation>Department of Botany, University of British Columbia, Vancouver, British Columbia, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Botany, University of British Columbia, Vancouver, British Columbia</wicri:regionArea><orgName type="university">Université de la Colombie-Britannique</orgName><placeName><settlement type="city">Vancouver</settlement><region type="state">Colombie-Britannique </region></placeName></affiliation></author><author><name sortKey="Street, Nathaniel R" sort="Street, Nathaniel R" uniqKey="Street N" first="Nathaniel R" last="Street">Nathaniel R. Street</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Physiology, Umeå Plant Science Centre, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Plant Physiology, Umeå Plant Science Centre, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Fladung, Matthias" sort="Fladung, Matthias" uniqKey="Fladung M" first="Matthias" last="Fladung">Matthias Fladung</name><affiliation wicri:level="1"><nlm:affiliation>Thünen Institute of Forest Genetics, Grosshansdorf, Germany. matthias.fladung@thuenen.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Thünen Institute of Forest Genetics, Grosshansdorf</wicri:regionArea><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32483326</idno><idno type="pmid">32483326</idno><idno type="doi">10.1038/s41477-020-0672-9</idno><idno type="wicri:Area/Main/Corpus">000275</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000275</idno><idno type="wicri:Area/Main/Curation">000275</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000275</idno><idno type="wicri:Area/Main/Exploration">000275</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A single gene underlies the dynamic evolution of poplar sex determination.</title><author><name sortKey="Muller, Niels A" sort="Muller, Niels A" uniqKey="Muller N" first="Niels A" last="Müller">Niels A. Müller</name><affiliation wicri:level="1"><nlm:affiliation>Thünen Institute of Forest Genetics, Grosshansdorf, Germany. niels.mueller@thuenen.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Thünen Institute of Forest Genetics, Grosshansdorf</wicri:regionArea><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion></affiliation></author><author><name sortKey="Kersten, Birgit" sort="Kersten, Birgit" uniqKey="Kersten B" first="Birgit" last="Kersten">Birgit Kersten</name><affiliation wicri:level="1"><nlm:affiliation>Thünen Institute of Forest Genetics, Grosshansdorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Thünen Institute of Forest Genetics, Grosshansdorf</wicri:regionArea><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion></affiliation></author><author><name sortKey="Leite Montalvao, Ana P" sort="Leite Montalvao, Ana P" uniqKey="Leite Montalvao A" first="Ana P" last="Leite Montalvão">Ana P. Leite Montalvão</name><affiliation wicri:level="1"><nlm:affiliation>Thünen Institute of Forest Genetics, Grosshansdorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Thünen Institute of Forest Genetics, Grosshansdorf</wicri:regionArea><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion></affiliation></author><author><name sortKey="M Hler, Niklas" sort="M Hler, Niklas" uniqKey="M Hler N" first="Niklas" last="M Hler">Niklas M Hler</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Physiology, Umeå Plant Science Centre, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Plant Physiology, Umeå Plant Science Centre, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Bernhardsson, Carolina" sort="Bernhardsson, Carolina" uniqKey="Bernhardsson C" first="Carolina" last="Bernhardsson">Carolina Bernhardsson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Biology, Linnean Centre for Plant Biology, Swedish University of Agricultural Sciences, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Plant Biology, Linnean Centre for Plant Biology, Swedish University of Agricultural Sciences, Uppsala</wicri:regionArea><wicri:noRegion>Uppsala</wicri:noRegion></affiliation></author><author><name sortKey="Br Utigam, Katharina" sort="Br Utigam, Katharina" uniqKey="Br Utigam K" first="Katharina" last="Br Utigam">Katharina Br Utigam</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biology, University of Toronto Mississauga, Mississauga, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Biology, University of Toronto Mississauga, Mississauga, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Carracedo Lorenzo, Zulema" sort="Carracedo Lorenzo, Zulema" uniqKey="Carracedo Lorenzo Z" first="Zulema" last="Carracedo Lorenzo">Zulema Carracedo Lorenzo</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Physiology, Umeå Plant Science Centre, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Plant Physiology, Umeå Plant Science Centre, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Hoenicka, Hans" sort="Hoenicka, Hans" uniqKey="Hoenicka H" first="Hans" last="Hoenicka">Hans Hoenicka</name><affiliation wicri:level="1"><nlm:affiliation>Thünen Institute of Forest Genetics, Grosshansdorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Thünen Institute of Forest Genetics, Grosshansdorf</wicri:regionArea><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion></affiliation></author><author><name sortKey="Kumar, Vikash" sort="Kumar, Vikash" uniqKey="Kumar V" first="Vikash" last="Kumar">Vikash Kumar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Physiology, Umeå Plant Science Centre, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Plant Physiology, Umeå Plant Science Centre, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Mader, Malte" sort="Mader, Malte" uniqKey="Mader M" first="Malte" last="Mader">Malte Mader</name><affiliation wicri:level="1"><nlm:affiliation>Thünen Institute of Forest Genetics, Grosshansdorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Thünen Institute of Forest Genetics, Grosshansdorf</wicri:regionArea><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion></affiliation></author><author><name sortKey="Pakull, Birte" sort="Pakull, Birte" uniqKey="Pakull B" first="Birte" last="Pakull">Birte Pakull</name><affiliation wicri:level="1"><nlm:affiliation>Thünen Institute of Forest Genetics, Grosshansdorf, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Thünen Institute of Forest Genetics, Grosshansdorf</wicri:regionArea><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion></affiliation></author><author><name sortKey="Robinson, Kathryn M" sort="Robinson, Kathryn M" uniqKey="Robinson K" first="Kathryn M" last="Robinson">Kathryn M. Robinson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Physiology, Umeå Plant Science Centre, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Plant Physiology, Umeå Plant Science Centre, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Sabatti, Maurizio" sort="Sabatti, Maurizio" uniqKey="Sabatti M" first="Maurizio" last="Sabatti">Maurizio Sabatti</name><affiliation wicri:level="1"><nlm:affiliation>Department for Innovation in Biological, Agro-food and Forest Systems, University of Tuscia, Viterbo, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department for Innovation in Biological, Agro-food and Forest Systems, University of Tuscia, Viterbo</wicri:regionArea><wicri:noRegion>Viterbo</wicri:noRegion></affiliation></author><author><name sortKey="Vettori, Cristina" sort="Vettori, Cristina" uniqKey="Vettori C" first="Cristina" last="Vettori">Cristina Vettori</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biosciences and BioResources, Division of Florence, National Research Council, Sesto Fiorentino, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Biosciences and BioResources, Division of Florence, National Research Council, Sesto Fiorentino</wicri:regionArea><wicri:noRegion>Sesto Fiorentino</wicri:noRegion></affiliation></author><author><name sortKey="Ingvarsson, P R K" sort="Ingvarsson, P R K" uniqKey="Ingvarsson P" first="P R K" last="Ingvarsson">P R K. Ingvarsson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Biology, Linnean Centre for Plant Biology, Swedish University of Agricultural Sciences, Uppsala, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Plant Biology, Linnean Centre for Plant Biology, Swedish University of Agricultural Sciences, Uppsala</wicri:regionArea><wicri:noRegion>Uppsala</wicri:noRegion></affiliation></author><author><name sortKey="Cronk, Quentin" sort="Cronk, Quentin" uniqKey="Cronk Q" first="Quentin" last="Cronk">Quentin Cronk</name><affiliation wicri:level="4"><nlm:affiliation>Department of Botany, University of British Columbia, Vancouver, British Columbia, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Botany, University of British Columbia, Vancouver, British Columbia</wicri:regionArea><orgName type="university">Université de la Colombie-Britannique</orgName><placeName><settlement type="city">Vancouver</settlement><region type="state">Colombie-Britannique </region></placeName></affiliation></author><author><name sortKey="Street, Nathaniel R" sort="Street, Nathaniel R" uniqKey="Street N" first="Nathaniel R" last="Street">Nathaniel R. Street</name><affiliation wicri:level="1"><nlm:affiliation>Department of Plant Physiology, Umeå Plant Science Centre, Umeå, Sweden.</nlm:affiliation><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Plant Physiology, Umeå Plant Science Centre, Umeå</wicri:regionArea><wicri:noRegion>Umeå</wicri:noRegion></affiliation></author><author><name sortKey="Fladung, Matthias" sort="Fladung, Matthias" uniqKey="Fladung M" first="Matthias" last="Fladung">Matthias Fladung</name><affiliation wicri:level="1"><nlm:affiliation>Thünen Institute of Forest Genetics, Grosshansdorf, Germany. matthias.fladung@thuenen.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Thünen Institute of Forest Genetics, Grosshansdorf</wicri:regionArea><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion><wicri:noRegion>Grosshansdorf</wicri:noRegion></affiliation></author></analytic><series><title level="j">Nature plants</title><idno type="eISSN">2055-0278</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although hundreds of plant lineages have independently evolved dioecy (that is, separation of the sexes), the underlying genetic basis remains largely elusive<sup>1</sup>. Here we show that diverse poplar species carry partial duplicates of the ARABIDOPSIS RESPONSE REGULATOR 17 (ARR17) orthologue in the male-specific region of the Y chromosome. These duplicates give rise to small RNAs apparently causing male-specific DNA methylation and silencing of the ARR17 gene. CRISPR-Cas9-induced mutations demonstrate that ARR17 functions as a sex switch, triggering female development when on and male development when off. Despite repeated turnover events, including a transition from the XY system to a ZW system, the sex-specific regulation of ARR17 is conserved across the poplar genus and probably beyond. Our data reveal how a single-gene-based mechanism of dioecy can enable highly dynamic sex-linked regions and contribute to maintaining recombination and integrity of sex chromosomes.</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">32483326</PMID><DateRevised><Year>2020</Year><Month>10</Month><Day>08</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2055-0278</ISSN><JournalIssue CitedMedium="Internet"><Volume>6</Volume><Issue>6</Issue><PubDate><Year>2020</Year><Month>06</Month></PubDate></JournalIssue><Title>Nature plants</Title><ISOAbbreviation>Nat Plants</ISOAbbreviation></Journal><ArticleTitle>A single gene underlies the dynamic evolution of poplar sex determination.</ArticleTitle><Pagination><MedlinePgn>630-637</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/s41477-020-0672-9</ELocationID><Abstract><AbstractText>Although hundreds of plant lineages have independently evolved dioecy (that is, separation of the sexes), the underlying genetic basis remains largely elusive<sup>1</sup>. Here we show that diverse poplar species carry partial duplicates of the ARABIDOPSIS RESPONSE REGULATOR 17 (ARR17) orthologue in the male-specific region of the Y chromosome. These duplicates give rise to small RNAs apparently causing male-specific DNA methylation and silencing of the ARR17 gene. CRISPR-Cas9-induced mutations demonstrate that ARR17 functions as a sex switch, triggering female development when on and male development when off. Despite repeated turnover events, including a transition from the XY system to a ZW system, the sex-specific regulation of ARR17 is conserved across the poplar genus and probably beyond. Our data reveal how a single-gene-based mechanism of dioecy can enable highly dynamic sex-linked regions and contribute to maintaining recombination and integrity of sex chromosomes.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Müller</LastName><ForeName>Niels A</ForeName><Initials>NA</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-5213-042X</Identifier><AffiliationInfo><Affiliation>Thünen Institute of Forest Genetics, Grosshansdorf, Germany. niels.mueller@thuenen.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kersten</LastName><ForeName>Birgit</ForeName><Initials>B</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-9900-9133</Identifier><AffiliationInfo><Affiliation>Thünen Institute of Forest Genetics, Grosshansdorf, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Leite Montalvão</LastName><ForeName>Ana P</ForeName><Initials>AP</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-5583-2272</Identifier><AffiliationInfo><Affiliation>Thünen Institute of Forest Genetics, Grosshansdorf, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mähler</LastName><ForeName>Niklas</ForeName><Initials>N</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-2673-9113</Identifier><AffiliationInfo><Affiliation>Department of Plant Physiology, Umeå Plant Science Centre, Umeå, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bernhardsson</LastName><ForeName>Carolina</ForeName><Initials>C</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-3258-275X</Identifier><AffiliationInfo><Affiliation>Department of Plant Biology, Linnean Centre for Plant Biology, Swedish University of Agricultural Sciences, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bräutigam</LastName><ForeName>Katharina</ForeName><Initials>K</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-5655-7156</Identifier><AffiliationInfo><Affiliation>Department of Biology, University of Toronto Mississauga, Mississauga, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carracedo Lorenzo</LastName><ForeName>Zulema</ForeName><Initials>Z</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-5321-6492</Identifier><AffiliationInfo><Affiliation>Department of Plant Physiology, Umeå Plant Science Centre, Umeå, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hoenicka</LastName><ForeName>Hans</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Thünen Institute of Forest Genetics, Grosshansdorf, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kumar</LastName><ForeName>Vikash</ForeName><Initials>V</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-1670-3491</Identifier><AffiliationInfo><Affiliation>Department of Plant Physiology, Umeå Plant Science Centre, Umeå, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mader</LastName><ForeName>Malte</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Thünen Institute of Forest Genetics, Grosshansdorf, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pakull</LastName><ForeName>Birte</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Thünen Institute of Forest Genetics, Grosshansdorf, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Robinson</LastName><ForeName>Kathryn M</ForeName><Initials>KM</Initials><AffiliationInfo><Affiliation>Department of Plant Physiology, Umeå Plant Science Centre, Umeå, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sabatti</LastName><ForeName>Maurizio</ForeName><Initials>M</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-7576-2112</Identifier><AffiliationInfo><Affiliation>Department for Innovation in Biological, Agro-food and Forest Systems, University of Tuscia, Viterbo, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vettori</LastName><ForeName>Cristina</ForeName><Initials>C</Initials><Identifier Source="ORCID">http://orcid.org/0000-0003-2475-773X</Identifier><AffiliationInfo><Affiliation>Institute of Biosciences and BioResources, Division of Florence, National Research Council, Sesto Fiorentino, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ingvarsson</LastName><ForeName>Pär K</ForeName><Initials>PK</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-9225-7521</Identifier><AffiliationInfo><Affiliation>Department of Plant Biology, Linnean Centre for Plant Biology, Swedish University of Agricultural Sciences, Uppsala, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cronk</LastName><ForeName>Quentin</ForeName><Initials>Q</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-4027-7368</Identifier><AffiliationInfo><Affiliation>Department of Botany, University of British Columbia, Vancouver, British Columbia, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Street</LastName><ForeName>Nathaniel R</ForeName><Initials>NR</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-6031-005X</Identifier><AffiliationInfo><Affiliation>Department of Plant Physiology, Umeå Plant Science Centre, Umeå, Sweden.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fladung</LastName><ForeName>Matthias</ForeName><Initials>M</Initials><Identifier Source="ORCID">http://orcid.org/0000-0001-9301-8581</Identifier><AffiliationInfo><Affiliation>Thünen Institute of Forest Genetics, Grosshansdorf, Germany. matthias.fladung@thuenen.de.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>06</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nat Plants</MedlineTA><NlmUniqueID>101651677</NlmUniqueID><ISSNLinking>2055-0278</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2019</Year><Month>12</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>04</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>6</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>6</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>6</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32483326</ArticleId><ArticleId IdType="doi">10.1038/s41477-020-0672-9</ArticleId><ArticleId IdType="pii">10.1038/s41477-020-0672-9</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li><li>Canada</li><li>Italie</li><li>Suède</li></country><region><li>Colombie-Britannique </li></region><settlement><li>Vancouver</li></settlement><orgName><li>Université de la Colombie-Britannique</li></orgName></list><tree><country name="Allemagne"><noRegion><name sortKey="Muller, Niels A" sort="Muller, Niels A" uniqKey="Muller N" first="Niels A" last="Müller">Niels A. Müller</name></noRegion><name sortKey="Fladung, Matthias" sort="Fladung, Matthias" uniqKey="Fladung M" first="Matthias" last="Fladung">Matthias Fladung</name><name sortKey="Hoenicka, Hans" sort="Hoenicka, Hans" uniqKey="Hoenicka H" first="Hans" last="Hoenicka">Hans Hoenicka</name><name sortKey="Kersten, Birgit" sort="Kersten, Birgit" uniqKey="Kersten B" first="Birgit" last="Kersten">Birgit Kersten</name><name sortKey="Leite Montalvao, Ana P" sort="Leite Montalvao, Ana P" uniqKey="Leite Montalvao A" first="Ana P" last="Leite Montalvão">Ana P. Leite Montalvão</name><name sortKey="Mader, Malte" sort="Mader, Malte" uniqKey="Mader M" first="Malte" last="Mader">Malte Mader</name><name sortKey="Pakull, Birte" sort="Pakull, Birte" uniqKey="Pakull B" first="Birte" last="Pakull">Birte Pakull</name></country><country name="Suède"><noRegion><name sortKey="M Hler, Niklas" sort="M Hler, Niklas" uniqKey="M Hler N" first="Niklas" last="M Hler">Niklas M Hler</name></noRegion><name sortKey="Bernhardsson, Carolina" sort="Bernhardsson, Carolina" uniqKey="Bernhardsson C" first="Carolina" last="Bernhardsson">Carolina Bernhardsson</name><name sortKey="Carracedo Lorenzo, Zulema" sort="Carracedo Lorenzo, Zulema" uniqKey="Carracedo Lorenzo Z" first="Zulema" last="Carracedo Lorenzo">Zulema Carracedo Lorenzo</name><name sortKey="Ingvarsson, P R K" sort="Ingvarsson, P R K" uniqKey="Ingvarsson P" first="P R K" last="Ingvarsson">P R K. Ingvarsson</name><name sortKey="Kumar, Vikash" sort="Kumar, Vikash" uniqKey="Kumar V" first="Vikash" last="Kumar">Vikash Kumar</name><name sortKey="Robinson, Kathryn M" sort="Robinson, Kathryn M" uniqKey="Robinson K" first="Kathryn M" last="Robinson">Kathryn M. Robinson</name><name sortKey="Street, Nathaniel R" sort="Street, Nathaniel R" uniqKey="Street N" first="Nathaniel R" last="Street">Nathaniel R. Street</name></country><country name="Canada"><noRegion><name sortKey="Br Utigam, Katharina" sort="Br Utigam, Katharina" uniqKey="Br Utigam K" first="Katharina" last="Br Utigam">Katharina Br Utigam</name></noRegion><name sortKey="Cronk, Quentin" sort="Cronk, Quentin" uniqKey="Cronk Q" first="Quentin" last="Cronk">Quentin Cronk</name></country><country name="Italie"><noRegion><name sortKey="Sabatti, Maurizio" sort="Sabatti, Maurizio" uniqKey="Sabatti M" first="Maurizio" last="Sabatti">Maurizio Sabatti</name></noRegion><name sortKey="Vettori, Cristina" sort="Vettori, Cristina" uniqKey="Vettori C" first="Cristina" last="Vettori">Cristina Vettori</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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